Glutathione is a critical molecule found in every cell of the body, with particularly high concentrations in the liver and skin. It’s not an exaggeration to state that any symptom, anywhere in the body can be tied to a deficiency in glutathione.
In my clinical experience, glutathione deficiency is one of the most common and far-reaching biochemical imbalances—and one of the most important to address. After 25 years of working with body chemistry, I recommend glutathione more than almost any other nutrient.
What Is Glutathione?
Glutathione is composed of three amino acids: glutamine, cysteine, and glycine. It is produced naturally in the body and serves primarily as a master antioxidant, defending cells against damage from toxins, free radicals, and oxidative stress.
The Aging Connection
Although it was first identified in the 1920s, glutathione gained widespread attention in the early 2000s due to its role in aging and disease prevention. We now know that the body’s ability to produce glutathione declines significantly with age:
- By approximately 30% by age 40
- And up to 50% by age 65
This decline has been linked to an increased risk of chronic disease, slower healing, and lower resilience overall.
Signs of Deficiency
Because glutathione is involved in almost every cellular process, its deficiency can manifest in many ways:
- Weakened immune function
- Recurring illnesses, increased susceptibility to infections, and—for some women—frequent UTIs may be signs of depletion.
- Liver stress
- The liver relies heavily on glutathione to detoxify chemicals, medications, alcohol, and other environmental toxins. When levels are low, the liver may be unable to keep up.
- Fatigue and poor energy production
- Glutathione plays a role in mitochondrial function. Low levels may lead to feelings of sluggishness or physical weakness.
- Accelerated aging
- Without sufficient antioxidant protection, cellular damage accumulates more rapidly, potentially contributing to the onset of age-related disease.
- Poor recovery
- Whether recovering from illness, injury, or emotional stress, low glutathione levels can slow healing and prolong inflammation.
How the Body Gets Glutathione
Glutathione is manufactured in the body, but it requires the right raw materials—especially cysteine, glycine, and glutamate. These can be obtained through diet.
Foods that support glutathione production include:
- Asparagus (among the highest sources)
- Spinach
- Avocados
- Okra
- Broccoli
- Brussels sprouts
- Cauliflower
- Cabbage
- Kale
Light cooking or eating some of these foods raw is recommended, as glutathione is sensitive to heat.
When supplementation is needed
While many people can maintain adequate glutathione through diet and lifestyle, chronic stress, illness, poor nutrition, and genetic factors can interfere with production and accelerate depletion.
Because the body’s chemistry is constantly shifting, individual assessment is key. When in doubt, consult a practitioner trained in applied kinesiology or functional diagnostics to determine the most effective supplementation and dietary support for your current condition.
A Personal Note to My Upper West Side Clients
Please accept my sincere apologies for any inconvenience my recent relocation may have caused. I hope you’ll find that my Midtown office is still conveniently located near beautiful Bryant Park, and offers a comfortable setting for your continued care.